Year : 1983 | Volume
: 31 | Issue : 7 | Page : 827--829
Fibrinolytic activity in blood and aqueous humour in glaucoma
KS Mehra, B Dube, RK Dube
Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
K S Mehra
Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005
|How to cite this article:|
Mehra K S, Dube B, Dube R K. Fibrinolytic activity in blood and aqueous humour in glaucoma.Indian J Ophthalmol 1983;31:827-829
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Mehra K S, Dube B, Dube R K. Fibrinolytic activity in blood and aqueous humour in glaucoma. Indian J Ophthalmol [serial online] 1983 [cited 2022 Sep 27 ];31:827-829
Available from: https://www.ijo.in/text.asp?1983/31/7/827/29677
MATERIALS AND METHODS
The patients under this study were divided into two groups: Group-A of seven patients, who were under going senile cataract surgery, and Group-B of another seven patients with untreated chronic simple glaucoma. None of these fourteen patients had any other local or systemic disease. Aqueous humour was obtained pre-operatively from both of these groups. The fluid was transported to the laboratory, cooled in an ice bucket and the tests for fibrinolytic activity'- were put up within half an hour of collection. Basal fibrinolytic potential of blood was also determined in both these groups.
The aqueous humour from all the seven patietnts, with senile cataract, showed conspicuous lysis on human fibrin plate; tthe area of lysis ranged from 110 mm 2 to 900 mm2 with an average of 423 mm 2. In contrast the aqueous from as many as six out of seven glaucoma patients, shows complete absence of lysis on human fibrin plate, the remaining one case showed a small lysis on a zone of 42 mm 1 (significant statistical difference was there / 0.01) [Table 1]. Thus from this it appears that plasminogen activator is more or less absent in aqueous of glaucoma patients.
None of the samples from either group showed lysis on bovine fibrin plate. On adding streptokinase to acueous, 6 out of seven samples from cataract group showed lysis on bovine fibrin plate (mean 49.4 mm2) thus indicating presence of plasminogen in six patients. Similaly streptokinase + aqueous mixture in. glaucoma group showed lysis on bovine fibrin plate in only three out of seven samples. [Table 1] i.e. plasminogen activity is also less in aqueous of glaucoma patients in comparison to normal aqueous (mean : Whitney Test showed a significant difference at 1 % level).
It was also observed that basal fibrinolytic activity and fibrinolytic potential of blood was much reduced in glaucoma group in comparison to normal group of patients (p - aqueous humour from cataract patients as also reported by Saiduzaffar. Absence of lysis on bovine fibrin,plate probably implies absence of proactivator in aqueous humour. Small amout of plasminogen appears to be present in majority of these patients, as inferred from aqueous + streptokinase experiment.
It is obvious [Table 1] that there is marked depression of plasminogen activator activity and plasminogen in aqueous in glaucoma patients and its etiopathogenic implication in such patients appears significant. It is likely that depressed fibrinolysis predisposes to fibrin deposition in the angle of anterior chamber, which increases the resistance to aqueous out-flow and thus, results in increased intraocular tension.
It is interesting to note that eyes having chronic simple glaucoma are more prone to develope thrombosis of central retinal vein. This association of depressed plasminogen activator activity in the blood as well as aqueous in glaucoma patients may be making them more susceptible for getting thrombosis of central retinal vein and vice versa. The therapeutic approach of enhancing fibrinolytic activity in chronic simple glaucoma patients may prove rewarding.
In seven patients of chronic simple glaucoma fibrinolytic activity of blood and aqueous humour was tested by Astrup fibrin plate lysis technique and compared with a control group of seven patients with senile cataract. The plasminogen activator content of blood and aqueous humour in glaucoma patients was remarkably reduced i.e. blood (p<0.01), (Mean Whitney test showed a significatnt difference at 1 % level). The want of aqueous fibrinolytic activity may have a pathogenetic implication for glaucoma since deposition of fibrin in the angle of eye, due to depressed fibrinolytic activity, could well increase resistance to aqueous out flow. Further, reduced fibrinolytic activity of blood in glaucoma patients may make them more susceptible for getting thrombosis of central retinal vein or vice versa
|1||Saiduzzaffar, H. 1970, Expt. Eve Research. 10:293.|
|2||Vannas and Tarkkan. E:.1960. Brit. J. Ophthamol. 44:5~3|
|3||Bertelesen:. 1961. Acta Ophthalmol. 39:603.|