Indian Journal of Ophthalmology

: 1983  |  Volume : 31  |  Issue : 7  |  Page : 890--891

B & T cell study in cases of Eales' disease by using a range of exciting antigens'

RN Mishra, SK Satangi Jamal Ahmed, VP Sardana 
 State Institute of Ophthalomolgy at Govt. M.D. Eye Hospital Allahabad, India

Correspondence Address:
R N Mishra
State Institute of Ophthalmology at Govt. M.D. Eye Hospital, Allahabad

How to cite this article:
Mishra R N, Satangi Jamal Ahmed S K, Sardana V P. B & T cell study in cases of Eales' disease by using a range of exciting antigens'.Indian J Ophthalmol 1983;31:890-891

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Mishra R N, Satangi Jamal Ahmed S K, Sardana V P. B & T cell study in cases of Eales' disease by using a range of exciting antigens'. Indian J Ophthalmol [serial online] 1983 [cited 2021 Sep 21 ];31:890-891
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Full Text

Eales' disease is a disorder of obscure etiol­ogy in which affected vessels are sheathed in a lymphocytic exudate and are liable to throm­bose with subsequent haemorrhage, neo­vascularization and scar tissue formation. Serum levels of IgG & IgA have been shown to be raised in Eales[1] diseases Koliopoulous et a1[2] reported reduced IgM levels. Antibodies to cell nuclei, mitochondria, smooth muscle and gastric partietal cells in some patients were shown.[3] Misra et a1[4] showed delayed hyper­sensitivity against tubercular antigen in majority of cases.

These studies suggest immunological pro­cess in the etiopathogenesis of Eales' disease, exact nature of which is still hypothetical. It is possible that a range of existing antigens are implicated. In this work we studied the `B' & `T' cell reaction against tubercular uveal and retinal-antigens.


Patients of Eales' disease attending the outdoor or indoor of State Institute of Ophthalmology at M.D. Eye Hospital, Allahabad were studied.

Diagnosis of the disease was confirmed by direct and indirect Opthalmoscopy and by S/ L Exam. with three mirror contact lens.

Blood was collected prior to any treatment and sera was tested by heamaggulitination technique for antibodies against tubercular, uveal and retinal antigen by the same method which was adopted in our previous study.[5] The same blood was tested for sensitized `T lymphocytes by leucocyte-migration inhibi­tion test against the same antigens. Method adopted was same, as was in our previous study.[4]


The study showed the following results.

[Table 1] showing the presence of antibodies against tubercular antigen in two cases and against uveal in one case.

[Table 2] depicts that 6 out of 7 cases are sen­sitized against tubercular antigen while no case was found to be sensitized against uveal or retinal antigens.

The study showed the presence of anti­bodies against the tubercular antigen in 2 cases and against uveal antigen in 1 case. The strength of uveal antibodies was significant i.e. 1/40 dilution.

While the same blood when tested for sen­sitized lymphocytes the 6 patients were found to be sensitive against tubercular antigens while none was against uveal and retinal antigens.


Though the study was possible in a limited number of the patients, still the `T' cell sen­sitivity against tubercular protein was found in the majority of the cases i.e. in about 85% of the cases. Sensitized lymphocytes against uveal and retinal antigen could not be demonstrated. Our study Coincides with the study of previous workers.[4],[6] Here it may also be possible that this high incidence may be the part of the mass sensitization of the popu­lation against tubercular antigen which was seen in about 80% of the population.

The significant rise of antiuveal antibodies in one case (1:40) suggest some sharing of uveal antigen in cases of periphalebitis retinae. The same relationship is not quoted in literature. Howsoever the presence of antiuveal antibodies in normal persons and in patients of other eye diseases[7] was shown in low concentration (1:10 to 1:20). This was explained on the basis of the formation of antibodies against the various cellular com­ponents like cell-nuclei, mitochondrine etc. Antiuveal antibodies may thus in our case, be of some reason. But the raised concentration of antiuveal antibodies in our case hence sug­gests involvement of uveal antigen in the etiopathogenosis of Eales' disease. However as the study is in a limited number of cases further more study is needed to elaborate the relationship of uveal antigen with that of periphlebitis, which is still going on.


This study suggests:­

(a) That incidence of periphlebitis retinae is high in tubercular sensitized person.

(b) That the `T' cell sensitization against uveal and retinal antigen is absent.

(c) That the sharing of uveal antigen in the etiopathogenesis of Eales' disease is possible.


1Johnson G.J. and Bloch KJ. 1969, Arch. Ophthalmol. 81, 322-24.
2Koliopoulos J.X., Perkins E.S. and Seitanides B.E. 1970, Brit. J. Ophthalmol 54, 233-36.
3Chilman T. 1973, Trans. Ophthalmol Soc. UK, 93, 193-98.
4Mishra R.N. et al. 1981 (Paper presented at All India Ophthalmological Conference).
5Mishra RN., Rahi, A.H.S. and Morgan, G. Brit. J. Ophthal. Volume 61, No. 4, P. 285-96, April (1977).
6Ashton N. 1962 Pathogenesis and artiology of Eales' disease. XIX Concimium Ophthalmologicum, 828-840.
7Mishra RN. et al. 1979 (Paper presented atAli India Ophthalmological Conference).