Year : 1983 | Volume
: 31 | Issue : 7 | Page : 964--965
Heredity in lattice degeneration of the retina
Manoj Shukla, OP Ahuja
A.M. U Institute of Ophthalmology, Aligarh, India
A.M. U Institute of Ophthalmology, Aligarh
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Shukla M, Ahuja O P. Heredity in lattice degeneration of the retina.Indian J Ophthalmol 1983;31:964-965
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Shukla M, Ahuja O P. Heredity in lattice degeneration of the retina. Indian J Ophthalmol [serial online] 1983 [cited 2021 Dec 4 ];31:964-965
Available from: https://www.ijo.in/text.asp?1983/31/7/964/29718
Lattice degeneration of the retina is the most common cause of retinal detchment. In a previous study we described the possible role of certain hereditary factors in the etiopathogenesis of this condition. The present study was undertaken to find out the association of heredity and lattice degeneration of the retina.
MATERIAL AND METHODS
78 family members of 19 subjects having lattice degeneration of the retina in different stages of its evolution [Table 1] were examined after maximal dilatation of pupils by an indirect ophthalmoscope and scleral depressor. This was supplemented by posterior segment biomicroscopy with the help of a Goldmann's three mirror contact lens in eyes having lattice degeneration of the retina. The findings were recorded on a conventional fundus topography chart.
Lattice degeneration of the retina was seen in family members of 9(47.37%) subjects out of 19 studied. A total of 38 family members of these 9 subjects were examined and lattice degeneration of the retina was seen in 16(42.11%) of them. 4 out of 19 subjects had extensive (360°) lattice degeneration. Interestingly one family member each of two of these subjects also had similar extensive lesions. Family members of another subject having extensive lattice lesions revealed isolated lesions while family members of fourth subject did not reveal lattice lesions. Itwas further significant to observe that fifty percent or more family members of 4 subjects were affected with lattice degeneration which was associated with partial thickness round holes in one family member each of two subjects.
Hereditary aspect of lattice degeneration of the retina has received comparatively lesser attention although clinical and histopathclogical features of this condition have been comprehensively described. Gartner described the familial occurence of lattice degeneration of the retina in non-myopic subjects, Everett suggested an autosomal dominant mode of inheritance with incomplete penetrance. Lewkonia et a1 observed lattice degeneration in 6 (10%) members out of 59 examined in a family of 110 members. The present study durther highlights the role of hereditary factors in the development of lattice degeneration of the retina. In this regard, long term family studies will be extremely important to exactly define the hereditary status of lattice degeneration. It is strongly advocated that family members of subjects having lattice degeneration of the retina should be meticulously examined to detect similar lesions in their eyes. Such an approach would also help in formulating guidelines for the prophylactic treatment of this condition in the prevention of retinal detachment.
78 family members of 19 subjects having lattice degeneration of the retina were examined to detect similar lesions in their eyes. Lattice degeneration was seen in 16 (42.11%) out of 38 family members of 9 subjects. It is believed that hereditary lat*ice degeneration is a specific disease process and as such long term family studies of subjects having lattice degeneration of the retina would be very informative specially with regards to prevention of retinal detachment caused by this condition.
|1||Shukla, M. and Ahuja O.P., 1981, Amer, J. Ophthalmol. 92: 482|
|2||Gertner, J., 1960, Klin. Mbl. Augenh. 136: 523|
|3||Everett. E.G., 1968, Amer, J. Ophthalmol. 65: 229|
|4||Lewkonia, I. Davis, M.S. and Salmon, T.D., 1973, Brit. J. Ophthalmol. 57 566|