Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 1991  |  Volume : 39  |  Issue : 4  |  Page : 174--175

Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes


K Sharma, PK Khosla, HK Tiwari, RK Sharma, JS Bajaj 
 Dr. Rajendra Prasad Centre for Ophthalmic Sciences, Department of Medicine, Department of Anatomy, All Institute of Medical Sciences, New Delhi, India

Correspondence Address:
K Sharma
Department of Neuro-Ophthalmology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Post Box 375, Lucknow - 226001
India

Juvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions and insulin resistance. The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabetic complications like microangiopathy is not very clear. In the present study, there was statistically a significant trend of higher insulin antibody binding levels in IDDM patients who developed retinopathy. Though there was a trend of higher insulin antibody in IDDM patients with retinopathy, there was no association between insulin antibody and HLA antigen which some authors have reported.


How to cite this article:
Sharma K, Khosla P K, Tiwari H K, Sharma R K, Bajaj J S. Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes.Indian J Ophthalmol 1991;39:174-175


How to cite this URL:
Sharma K, Khosla P K, Tiwari H K, Sharma R K, Bajaj J S. Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes. Indian J Ophthalmol [serial online] 1991 [cited 2021 Oct 20 ];39:174-175
Available from: https://www.ijo.in/article.asp?issn=0301-4738;year=1991;volume=39;issue=4;spage=174;epage=175;aulast=Sharma;type=0