Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 1993  |  Volume : 41  |  Issue : 2  |  Page : 74--77

The role of 5-fluorouracil in complicated glaucomas


AM Khan, FA Jilani, S Das 
 Institute of Ophthalmology, Aligarh Muslim University, Aligarh, India

Correspondence Address:
A M Khan
Institute of Ophthalmology, Aligarh Muslim University, Aligarh, U.P. 202002
India

The long-term efficacy of trabeculectomy in controlling intraocular pressure (IOP) has been found unsatisfactory in various complicated and refractory glaucomas. The most common cause for failure is excessive scarring at the filtering site. Several wound modulating agents which reduce scarring have been tested. In this study, 5-Fluorouracil (5-FU), a halogenated pyrimidine analogue and a potent anti-mitotic agent, was applied for seven days after trabeculectomy in eighteen complicated and unsuccessful filtering glaucomas, at a daily dosage of 5 mg in the form of 0.5 ml subconjunctival injections. The common postoperative complications encountered were corneal epithelial erosion (38%), wound leakage (16%), subconjunctival haemorrhage (32%) and hyphaema (10%), all during the first 7 to 10 days. Monitoring at regular intervals up to six months showed adequate control of IOP (less than 22mm Hg.) in 88% of the cases. Cases of aphakic glaucoma and neovascular glaucoma showed poor response. Use of 5-FU as an adjuvant to filtering surgery in various complicated glaucomas improves the long-term results


How to cite this article:
Khan A M, Jilani F A, Das S. The role of 5-fluorouracil in complicated glaucomas.Indian J Ophthalmol 1993;41:74-77


How to cite this URL:
Khan A M, Jilani F A, Das S. The role of 5-fluorouracil in complicated glaucomas. Indian J Ophthalmol [serial online] 1993 [cited 2022 Jan 25 ];41:74-77
Available from: https://www.ijo.in/article.asp?issn=0301-4738;year=1993;volume=41;issue=2;spage=74;epage=77;aulast=Khan;type=0