Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 1994  |  Volume : 42  |  Issue : 1  |  Page : 23--25

Metabolic factors in the development of retinopathy of juvenile-onset type I diabetes mellitus


PK Khosla, K Sharma, HK Tewari, JS Bajaj, MC Vaidya 
 R.P. Centre for Ophthalmic Sciences, and Departments of Medicine and Anatomy, ARMS, New Delhi, India

Correspondence Address:
K Sharma
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 002
India

Thirty-five patients of insulin-dependent diabetes mellitus (IDDM) were investigated for the effect of various metabolic factors on retinopathy. The severity of retinopathy increased with duration and age of onset of IDDM. Degree of glycaemia (fasting blood sugar, FBS) was similar in patients with or without retinopathy. All IDDM patients as a group showed severe carbohydrate intolerance with lower basal and post glucose serum immunoreactive insulin (IRI) levels and serum C-peptide radioimmunoreactivity (CPR) as compared to controls. The insulin secretory response was similar in no retinopathy, mild retinopathy and severe retinopathy groups. Patients with retinopathy had higher incidence of hyperlipidemia but mean serum levels of cholesterol and triglyceride were similar. This study does not suggest a direct relationship between the various metabolic factors studied and retinopathy due to IDDM


How to cite this article:
Khosla P K, Sharma K, Tewari H K, Bajaj J S, Vaidya M C. Metabolic factors in the development of retinopathy of juvenile-onset type I diabetes mellitus.Indian J Ophthalmol 1994;42:23-25


How to cite this URL:
Khosla P K, Sharma K, Tewari H K, Bajaj J S, Vaidya M C. Metabolic factors in the development of retinopathy of juvenile-onset type I diabetes mellitus. Indian J Ophthalmol [serial online] 1994 [cited 2021 Jun 23 ];42:23-25
Available from: https://www.ijo.in/article.asp?issn=0301-4738;year=1994;volume=42;issue=1;spage=23;epage=25;aulast=Khosla;type=0