Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2004  |  Volume : 52  |  Issue : 2  |  Page : 145--8

Trace Elements Iron, Copper and Zinc in Vitreous of Patients with Various Vitreoretinal Diseases


N Sulochana Konerirajapuram, K Coral, R Punitham, T Sharma, N Kasinathan, R Sivaramakrishnan 
 Biochemistry Research Department, Sankara Nethralaya, Chennai, India

Correspondence Address:
N Sulochana Konerirajapuram
Biochemistry Research Department, Sankara Nethralaya, Chennai
India

Purpose: To measure the concentrations of iron, copper and zinc in human vitreous and to interpret their levels with various vitreoretinal diseases like proliferative diabetic retinopathy, retinal detachment, intraocular foreign body, Eales«SQ» disease and macular hole. Methods: Undiluted vitreous fluid collected during pars plana vitrectomy was used to measure trace elements using an atomic absorption spectrophotometer. Results: The level of vitreous iron increased threefold in Eales«SQ» disease (1.85 ± 0.36 pg/ml), 2.5-fold in proliferative diabetic retinopathy (1.534 ± 0.17 pg/ml) and 2.3-fold in eyes with intraocular foreign body (1.341 ± 0.25 pg/ml) when compared with macular hole (0.588 ± 0.16 pg/ml). This was statistically significant (P < 0.05). Zinc was found to be low in Eales«SQ» disease (0.57 ± 0.22 pg/ml) when compared with other groups, though the difference was not statistically significant. Conclusion: The increased level of iron with decreased zinc content in Eales«SQ» disease confirms the earlier reported oxidative stress mechanism for the disease. In proliferative diabetic retinopathy and intraocular foreign body the level of iron increases. This is undesirable as iron can augment glycoxidation, which can lead to increased susceptibility to oxidative damage, in turn causing vitreous liquefaction, posterior vitreous detachment and ultimately retinal detachment and vision loss


How to cite this article:
Konerirajapuram N S, Coral K, Punitham R, Sharma T, Kasinathan N, Sivaramakrishnan R. Trace Elements Iron, Copper and Zinc in Vitreous of Patients with Various Vitreoretinal Diseases.Indian J Ophthalmol 2004;52:145-8


How to cite this URL:
Konerirajapuram N S, Coral K, Punitham R, Sharma T, Kasinathan N, Sivaramakrishnan R. Trace Elements Iron, Copper and Zinc in Vitreous of Patients with Various Vitreoretinal Diseases. Indian J Ophthalmol [serial online] 2004 [cited 2021 Jan 16 ];52:145-8
Available from: https://www.ijo.in/article.asp?issn=0301-4738;year=2004;volume=52;issue=2;spage=145;epage=8;aulast=Konerirajapuram;type=0