ORIGINAL ARTICLE
Year : 2005 | Volume
: 53 | Issue : 1 | Page : 23--30
Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India
Ravi Thomas1, Rajul Parikh2, Devendra Sood3, L Vijaya4, G Chandra Sekhar1, Narendra N Sood3, M Baskaran4, K Kalyani Prasad1
1 LV Prasad Eye Institute, India
2 Schell Eye Hospital, Christian Medical College, Vellore, India
3 Shroff Eye Hospital, New Delhi, India
4 Sankara Nethralaya , Chennai, India
Correspondence Address:
Ravi Thomas
LV Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad - 500 034
India
PURPOSE: To evaluate the short-term efficacy and safety of 0.005% topical latanoprost in Indian eyes. DESIGN: Prospective non-randomised open-label multicentric trial. METHODS: One hundred and fifty patients with ocular hypertension (OHT), primary open-angle, pseudoexfoliation or pigmentary glaucoma were enrolled at four centers. Each center contributed at least 20 patients. Following baseline measurements, 0.005% latanoprost was applied topically once daily in the evening for three months. Patients were examined at 2, 6 and 12 weeks. The primary outcome measure was mean intraocular pressure (IOP) reduction. The mean diurnal variation of IOP (difference between highest and lowest IOP) at baseline and at 12-weeks was compared. RESULTS: One hundred and thirty of 150 enrolled patients completed the study. One randomly selected eye of each patient was included for analysis. At three months, latanoprost reduced the mean IOP from 24.9 (± 3.16) mmHg at baseline to 16.10 (± 2.7) mmHg, a reduction of 35.25%. 83% had a reduction in IOP of > 25%. The IOP reduction was maintained throughout the study period, and was not affected by gender or age of the patient. One eye did not show any response to the drug. Daytime diurnal variation of IOP was reduced from 4.5 to 2.9 mmHg. 20 patients had conjunctival hyperemia. Six patients had side effects requiring withdrawal from the study. CONCLUSIONS: In this short-term multicentric study, latanoprost effectively reduced IOP and stabilised the diurnal curve in Indian eyes. There were no clinically significant ocular or systemic adverse effects.
How to cite this article:
Thomas R, Parikh R, Sood D, Vijaya L, Chandra Sekhar G, Sood NN, Baskaran M, Kalyani Prasad K. Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India
.Indian J Ophthalmol 2005;53:23-30
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How to cite this URL:
Thomas R, Parikh R, Sood D, Vijaya L, Chandra Sekhar G, Sood NN, Baskaran M, Kalyani Prasad K. Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India
. Indian J Ophthalmol [serial online] 2005 [cited 2023 Mar 20 ];53:23-30
Available from: https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2005;volume=53;issue=1;spage=23;epage=30;aulast=Thomas;type=0 |
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