Indian Journal of Ophthalmology

BRIEF COMMUNICATION
Year
: 2013  |  Volume : 61  |  Issue : 12  |  Page : 765--767

Evaluation of brimonidine-timolol fixed combination in patients of primary open-angle glaucoma


Sachin R Joshi, Pramod B Akat, Jaiprakash B Ramanand, Sunita J Ramanand, Vitthal B Karande, Suyog S Jain 
 Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India

Correspondence Address:
Pramod B Akat
Department of Pharmacology, Government Medical College, Miraj - 416 410, Maharashtra
India

The aim of present study was to compare the efficacy and safety of fixed combination of brimonidine and timolol with individual components used as monotherapy in patients of primary open angle glaucoma. Patients were randomly assigned to receive brimonidine or timolol or brimonidine-timolol fixed combination, with 30 patients in each group. The mean reduction in intraocular pressure in brimonidine, timolol, and brimonidine-timolol group were 4.29 ± 1.97 mm Hg, 4.34 ± 1.21 mm Hg, and 5.54 ± 1.87 mm Hg respectively at 2 weeks and 4.86 ± 1.16 mm Hg, 5.42 ± 1.50 mm Hg, and 7.36 ± 2.58 mm Hg respectively at 6 weeks. When values of mean reduction in intraocular pressure were compared between brimonidine-timolol fixed combination with brimonidine and timolol, it was found to be statistically significant ( P < 0.05) at 2 weeks and highly significant (0.001) at 6 weeks. The overall frequency of adverse effects was similar in all three groups.


How to cite this article:
Joshi SR, Akat PB, Ramanand JB, Ramanand SJ, Karande VB, Jain SS. Evaluation of brimonidine-timolol fixed combination in patients of primary open-angle glaucoma.Indian J Ophthalmol 2013;61:765-767


How to cite this URL:
Joshi SR, Akat PB, Ramanand JB, Ramanand SJ, Karande VB, Jain SS. Evaluation of brimonidine-timolol fixed combination in patients of primary open-angle glaucoma. Indian J Ophthalmol [serial online] 2013 [cited 2020 Oct 25 ];61:765-767
Available from: https://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=12;spage=765;epage=767;aulast=Joshi;type=0