Indian Journal of Ophthalmology

BRIEF COMMUNICATION
Year
: 2013  |  Volume : 61  |  Issue : 9  |  Page : 525--527

Comparison of efficiency of intravitreal ceftazidime and intravitreal cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis


Nurettin Deniz1, Orhan Aydemir2, Mete Güler3, Nusret Akpolat4, Ahmet Kizirgil5 
1 Department of Ophthalmology, Batman State Hospital, Batman, Turkey
2 Department of Ophthalmology, School of Medicine, Firat University, Elazig, Turkey
3 Adiyaman University, Adiyaman, Turkey
4 Department of Pathology, School of Medicine, Inönü University, Malatya, Turkey
5 Department of Microbiology, School of Medicine, Firat University, Elazig, Turkey

Correspondence Address:
Orhan Aydemir
Department of Ophthalmology, School of Medicine, Firat University, 23119 Elazig
Turkey

In this study, we evaluated the efficiency of cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis. We compared the findings with the standard dose of ceftazidime (1 mg/0.1 ml). Thirty-six New-Zealand White rabbits were divided into 6 equal groups and were treated with different methods (Group 1 = sham, Group 2 = 0.5 mg/0.1 ml cefepime, Group 3 = 1 mg/0.1 ml cefepime, Group 4 = 2 mg/0.1 ml cefepime, Group 5 = 1 mg/0.1 ml ceftazidime, Group 6 = control). The eyes of rabbits in each group were examined clinically on 1 st , 3 rd , and 6 th day of the experiment. At 6 th day, 0.1 ml vitreous humor aspirates were obtained and plated for quantification on the blood agar and the results were expressed as colony-forming unit/ml. Subsequently, the eyeballs were enucleated and the histopathological evaluation was performed. Our findings denoted beneficial effects of cefepime in treatment groups (especially, in Groups 3 and 4). Intravitreal cefepime may be an alternative drug in the treatment of P. aeruginosa endophthalmitis.


How to cite this article:
Deniz N, Aydemir O, Güler M, Akpolat N, Kizirgil A. Comparison of efficiency of intravitreal ceftazidime and intravitreal cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis.Indian J Ophthalmol 2013;61:525-527


How to cite this URL:
Deniz N, Aydemir O, Güler M, Akpolat N, Kizirgil A. Comparison of efficiency of intravitreal ceftazidime and intravitreal cefepime in the treatment of experimental Pseudomonas aeruginosa endophthalmitis. Indian J Ophthalmol [serial online] 2013 [cited 2021 Apr 16 ];61:525-527
Available from: https://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=9;spage=525;epage=527;aulast=Deniz;type=0