Indian Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 63  |  Issue : 4  |  Page : 318--322

Pulse cyclophosphamide therapy in the management of patients with macular serpiginous choroidopathy


Pradeep Venkatesh1, Varun Gogia1, Shikha Gupta1, Akshay Tayade1, Neha Shilpy1, Bhavin M Shah1, Randeep Guleria2 
1 Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
2 Department of Pulmonary Medicine, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Varun Gogia
Retina and Uvea Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi
India

Purpose: To evaluate safety and efficacy of intravenous pulse cyclophosphamide (CyP) in acute macular serpiginous choroiditis (SC). Methods: Patients with acute macular SC with lesions threatening and/or involving fovea were enrolled. All patients received CyP (1 g/m 2 ) for 3 days followed by high-dose oral steroids (1.5 mg/kg) tapered over 6 months and monitored for visual acuity, response to treatment and systemic side effects. Results: Eight patients (seven unilateral and one bilateral) with median age of 27 years (range: 13-40 years) were recruited. Mean visual acuity at presentation was 0.71 ± 0.35 logarithm of the minimum angle of resolution while postpulse visual acuity was 0.40 ± 0.32. Final mean visual acuity at 1-year was 0.31 ± 0.23 (P ≤ 0.05). Three eyes had recurrence and 3 patients developed transient hair loss with no other adverse effect. Conclusion: Intravenous CyP provides rapid resolution of lesion activity and thereby helps in maintaining good functional acuity.


How to cite this article:
Venkatesh P, Gogia V, Gupta S, Tayade A, Shilpy N, Shah BM, Guleria R. Pulse cyclophosphamide therapy in the management of patients with macular serpiginous choroidopathy.Indian J Ophthalmol 2015;63:318-322


How to cite this URL:
Venkatesh P, Gogia V, Gupta S, Tayade A, Shilpy N, Shah BM, Guleria R. Pulse cyclophosphamide therapy in the management of patients with macular serpiginous choroidopathy. Indian J Ophthalmol [serial online] 2015 [cited 2020 Oct 28 ];63:318-322
Available from: https://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=4;spage=318;epage=322;aulast=Venkatesh;type=0