Indian Journal of Ophthalmology

CASE REPORT
Year
: 2018  |  Volume : 66  |  Issue : 2  |  Page : 322--324

Real-time polymerase chain reaction in acute retinal necrosis following encephalitis


Vinita Rao, Jyotirmay Biswas, Gopal Lingam 
 Uveitis Service, Sankara Nethralaya, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Vinita Rao
Uveitis Service, Sankara Nethralaya, 18, College Road, Chennai - 600 006 Tamil Nadu
India

Acute retinal necrosis (ARN) following herpes simplex encephalitis (HSE) in an immunocompetent patient is a rare condition. Quantitative real-time polymerase chain reaction (qPCR) has made it possible to identify and quantify viral genome. We report a case of ARN following HSE managed with the help of qPCR. A 45-year-old man developed ARN following HSE and was treated with intravenous acyclovir and intravitreal foscarnet. The retinitis did not respond initially and the qPCR demonstrated a rise in the number of copies of the HSV-1 viral genome. With continued treatment with intravenous acyclovir and intravitreal ganciclovir, the retinitis healed and the qPCR confirmed a reduction in the viral load. qPCR has a high sensitivity and specificity for HSV and is a useful tool for diagnosis and treatment of viral retinitis.


How to cite this article:
Rao V, Biswas J, Lingam G. Real-time polymerase chain reaction in acute retinal necrosis following encephalitis.Indian J Ophthalmol 2018;66:322-324


How to cite this URL:
Rao V, Biswas J, Lingam G. Real-time polymerase chain reaction in acute retinal necrosis following encephalitis. Indian J Ophthalmol [serial online] 2018 [cited 2020 Oct 24 ];66:322-324
Available from: https://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=2;spage=322;epage=324;aulast=Rao;type=0