Indian Journal of Ophthalmology

LETTER TO THE EDITOR
Year
: 2020  |  Volume : 68  |  Issue : 1  |  Page : 261-

Response to comments on: Changes in pattern electroretinogram after application of 0.01% atropine eye drops


Mihir Kothari, Deepak Bhat, Nitu Khadse, Rishika Jain, Vivek Rathod 
 Jyotirmay Eye Clinic, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Mihir Kothari
Jyotirmay Eye Clinic, 104, 105 Kaalika Tower, Kolbad Road, Khopat, Thane West - 400 601, Maharashtra
India




How to cite this article:
Kothari M, Bhat D, Khadse N, Jain R, Rathod V. Response to comments on: Changes in pattern electroretinogram after application of 0.01% atropine eye drops.Indian J Ophthalmol 2020;68:261-261


How to cite this URL:
Kothari M, Bhat D, Khadse N, Jain R, Rathod V. Response to comments on: Changes in pattern electroretinogram after application of 0.01% atropine eye drops. Indian J Ophthalmol [serial online] 2020 [cited 2020 Oct 22 ];68:261-261
Available from: https://www.ijo.in/text.asp?2020/68/1/261/273224


Full Text



Dear Sir,

We are thankful to Jethani et al.[1] for their interest in our paper.[2] The reason for their “inability” to detect the changes in the pattern electroretinogram (PERG) following the instillations of 0.01% atropine eye drops may be due to a simple explanation.

Skin electrodes, used by Jethani et al., measure more than 100 μv and pick up more neural noise. The machine then processes the signal by complex averaging of the signals changing the actual result. DTL electrodes, used by us, are applied to the eye and capture very small and noise-free electrical signals ranging from just 1.0 μv to 20 μv. We caution the clinicians against the use of skin electrodes in obtaining the PERG, which is against the ISCEV standards.[3] The results obtained using different electrodes on different machines are not comparable.

The PERG changes with 0.01% atropine eye drops reported by us were real. However, it was an experimental condition where 4 drops of 0.01% atropine were applied in succession. It is possible that when only one drop of 0.01% atropine eye drops is applied once at night, no predictable changes might be recorded on PERG.[4]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Jethani J, Memon S. Comments on: Changes in pattern electroretinogram after application of 0.01% atropine eye drops. Indian J Ophthalmol 2020;68:259-61.
2Kothari M, Bhat D, Khadse N, Jain R, Rathod V, Aru P. Changes in pattern electroretinogram after application of 0.01% atropine eye drops. Indian J Ophthalmol 2019;67:309-10.
3Bach M, Brigell MG, Hawlina M, Holder GE, Johnson MA, McCulloch DL, et al. ISCEV standard AQ6 for clinical pattern electroretinography (PERG): 2012 update. Doc Ophthalmol 2013;126:1-7.
4Anders LM, Heinrich SP, Lagrèze WA, Joachimsen L. Little effect of 0.01% atropine eye drops as used in myopia prevention on the pattern electroretinogram. Doc Ophthalmol 2019;138:85-95.