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June 2013 Volume 61 | Issue 6
Page Nos. 251-313
Online since Thursday, June 27, 2013
Accessed 63,056 times.
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EDITORIAL |
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Meet the challenge |
p. 251 |
Sundaram Natarajan DOI:10.4103/0301-4738.114088 PMID:23803474 |
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GUEST EDITORIAL |
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Uveitis in developing countries |
p. 253 |
Narsing A Rao DOI:10.4103/0301-4738.114090 PMID:23803475 |
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SYMPOSIUM |
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Algorithmic approach in the diagnosis of uveitis  |
p. 255 |
SR Rathinam, Manohar Babu DOI:10.4103/0301-4738.114092 PMID:23803476Uveitis is caused by disorders of diverse etiologies including wide spectrum of infectious and non-infectious causes. Often clinical signs are less specific and shared by different diseases. On several occasions, uveitis represents diseases that are developing elsewhere in the body and ocular signs may be the first evidence of such systemic diseases. Uveitis specialists need to have a thorough knowledge of all entities and their work up has to be systematic and complete including systemic and ocular examinations. Creating an algorithmic approach on critical steps to be taken would help the ophthalmologist in arriving at the etiological diagnosis. |
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REVIEW ARTICLES |
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Ancillary investigations in uveitis |
p. 263 |
Vishali Gupta, Amod Gupta DOI:10.4103/0301-4738.114093 PMID:23803477Ancillary investigations are the backbone of uveitis work-up both for anterior and posterior segment diseases. They help in making the diagnosis, ruling out certain differential diagnosis and monitoring inflammation during the follow-up. This review aims to be an overview describing the role of commonly used investigations for uveitis. |
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Laboratory support in the diagnosis of uveitis |
p. 269 |
Parthopratim Dutta Majumder, S Sudharshan, Jyotirmay Biswas DOI:10.4103/0301-4738.114095 PMID:23803478Intraocular inflammations are still a diagnostic challenge for ophthalmologists. It is often difficult to make a precise etiological diagnosis in certain situations. Recently, there have been several advances in the investigations of uveitis, which has helped the ophthalmologists a lot in the management of such clinical conditions. A tailored approach to laboratory diagnosis of uveitic cases should be directed by the history, patient's symptoms and signs, and clinical examination. This review summarizes various modalities of laboratory investigations and their role in the diagnosis of uveitis. |
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Medical Management of Uveitis - Current Trends  |
p. 277 |
Kalpana Babu, Padmamalini Mahendradas DOI:10.4103/0301-4738.114099 PMID:23803479Uveitis is a challenging disease to treat. Corticosteroids have been used in the treatment of uveitis for many years. Immunosuppressives are gaining momentum in recent years in the treatment of uveitis. In this article we present an overview of current treatment of uveitis and the major breakthroughs and advances in drugs and ocular drug delivery systems in the treatment of uveitis. |
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Surgical management in patient with uveitis |
p. 284 |
Somasheila I Murthy, Rajeev Reddy Pappuru, K Madhavi Latha, Sripathi Kamat, Virender S Sangwan DOI:10.4103/0301-4738.114103 PMID:23803480Surgery in the management of uveitis can be divided based on indication: either for therapeutic or can be for diagnostic purposes or to manage complications. The commonest indications include: Visual rehabilitation: surgery for removal of cataract, band keratopathy, corneal scars, pupillary membranes, removal of dense vitreous membranes, management of complications: anti-glaucoma surgery, vitreous hemorrhage, retinal detachment and chronic hypotony and diagnostic: aqueous tap, vitreous biopsy, tissue biopsy (iris, choroid). In this review, we shall describe the surgical technique for visual rehabilitation and for management of complications. |
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PHOTOESSAY |
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Peripheral choroidal nodules in a case of proven systemic sarcoidosis |
p. 291 |
Vishnu Suryaprakash, Sanghamitra Kanungo, Jyotirmay Biswas DOI:10.4103/0301-4738.114105 PMID:23803481A case of sarcoidosis presenting as peripheral choroidal nodules has been described. |
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BRIEF COMMUNICATIONS |
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Red eye: Rule out Ophthalmomyiasis too |
p. 293 |
Pankaj Choudhary, Mahesh Kumar Rathore, Premchand Dwivedi, Sujata Lakhtakia, Charudatt Chalisgaonkar, Anamika Dwivedi DOI:10.4103/0301-4738.114107 PMID:23803482Ophthalmomyiasis is the infestation of human eye by the larvae of certain flies. Sheep botfly commonly manifests as Ophthalmomyiasis externa when there is conjunctival involvement or rarely as Opthalmomyiasis interna when there is larval penetration into the eyeball. It appears to be more common than what has been indicated by previously published reports. We present a report of seven cases of Ophthalmomyiasis by Oestrus ovis, from central India who presented with features of conjunctivitis varying between mild to severe. The larvae were seen in bulbar and palpebral conjunctiva and also entangled in lashes with discharge. Since the larvae are photophobic, it is prudent to look for them in the fornices and also in discharge. Prompt removal of the larvae from the conjunctiva helps in relieving the symptoms and also prevents serious complications. Taxonomic identification of the species is important to estimate the risk of globe penetration by the larvae. |
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Ocular toxoplasmosis associated with scleritis |
p. 295 |
Yogish S Kamath, SR Rathinam, Ankush Kawali DOI:10.4103/0301-4738.111130 PMID:23619485We report an atypical presentation of Toxoplasma retinochoroiditis with associated scleritis in a young and immunocompetent patient. The diagnosis was done on the basis of Polymerase chain reaction of vitreous sample, and the clinical response to specific treatment. This case highlights the unusual presentation of ocular toxoplasmosis as scleritis. |
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Periorbital dirofilariasis-Clinical and imaging findings: Live worm on ultrasound |
p. 298 |
Thandre N Gopinath, KP Lakshmi, PC Shaji, PC Rajalakshmi DOI:10.4103/0301-4738.114111 PMID:23803483Ocular dirofilariasis is a zoonotic filariasis caused by nematode worm,Dirofilaria. We present a case of dirofilariasis affecting the upper eyelid in a 2-year-old child presenting as an acutely inflammed cyst, from southern Indian state of Kerala. Live adult worm was surgically removed and confirmed to be Dirofilaria repens. Live worm showing continuous movement was seen on the pre-operative high-resolution ultrasound. Ultrasound can be helpful in pre-operative identification of live worm.Imaging findings reported in literature are very few. We describe the clinical, ultrasound, and magnetic resonance imaging (MRI) findings. |
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Granulomatous inflammation in Acanthamoeba sclerokeratitis |
p. 300 |
Samrat Chatterjee, Deepshikha Agrawal, Geeta K Vemuganti DOI:10.4103/0301-4738.99844 PMID:23552359This report describes the histopathological findings in a patient with Acanthamoeba sclerokeratitis (ASK). A 58-year-old patient with ASK underwent enucleation and sections of the cornea and sclera were subjected to histopathology and immunohistochemistry with monoclonal mouse antihuman antibodies against T cell CD3 and B cell CD20 antigens. Hematoxylin and Eosin stained sections of the cornea revealed epithelial ulceration, Bowman's membrane destruction, stromal vascularization, infiltration with lymphocytes, plasma cells, and granulomatous inflammation with multinucleated giant cells (MNGC). The areas of scleritis showed complete disruption of sclera collagen, necrosis and infiltration with neutrophils, macrophages, lymphocytes, and granulomatous inflammation with MNGC. No cyst or trophozoites of Acanthamoeba were seen in the cornea or sclera. Immunophenotyping revealed that the population of lymphocytes was predominantly of T cells. Granulomatous inflammation in ASK is probably responsible for the continuance and progression of the scleritis and management protocols should include immunosuppressive agents alongside amoebicidal drugs. |
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Serpiginous choroiditis and acute retinal necrosis occurring in the same patient |
p. 303 |
Aditi Gupta, Jyotirmay Biswas DOI:10.4103/0301-4738.99991 PMID:23571247We describe a rare association of serpiginous choroiditis with necrotizing retinitis having clinical features of acute retinal necrosis (ARN). A 23-year-old male developed ARN in the fellow eye while he was on tapering doses of immunosuppressive medications for unilateral serpiginous choroiditis. The association may represent a common viral etiology of the two diseases or may be due to the development of ARN due to general state of iatrogenic immunosuppression. This report also highlights the importance of a detailed evaluation of both the eyes on regular follow-up visits in the patients receiving iatrogenic immunosuppression. |
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Choroidal neovascularization secondary to choroidal nevus simulating an inflammatory lesion |
p. 305 |
Samuray Tuncer, Ilknur Tugal-Tutkun DOI:10.4103/0301-4738.99860 PMID:23571241Choroidal nevi are the most common benign pigmented lesions of the fundus. Choroidal neovascularization is a rare complication of choroidal nevi. We report herein a young patient managed successfully with intravitreal bevacizumab injections for juxtapapillary choroidal neovascularization secondary to choroidal nevus simulating an inflammatory lesion. |
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Orbital malignant melanoma associated with nevus of Ota |
p. 306 |
Cherungottil V Radhadevi, Kakkuzhiyil S Charles, Vasu K Lathika DOI:10.4103/0301-4738.109526 PMID:23571263Nevus of Ota (oculodermal melanosis) is a dermal melanocytic hamartoma with bluish hyperpigmentation along the first and second branches of the trigeminal nerve. Extracutaneous involvement, especially ocular, has been reported. A 45-year-old male presented with malignant melanoma of the left orbit in association with nevus of Ota. Being locally invasive, a modified exenteration with frontal flap repair was done on left eye. Adjuvant chemotherapy was given after wound healing. All pigmented lesions of the eye require close monitoring to help in the early diagnosis. Since malignant transformation has been reported in oculodermal melanosis, close follow-up and patient education will facilitate early diagnosis and prompt management. This case is reported for its rarity and unusual presentation. |
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Pseudomonas aeruginosa endophthalmitis masquerading as chronic uveitis |
p. 309 |
Kalpana Badami Nagaraj, Chaitra Jayadev DOI:10.4103/0301-4738.114122 PMID:23803484A 65-year-old male presented with decreased vision in the left eye of 15-day duration after having undergone an uneventful cataract surgery 10 months back. He had been previously treated with systemic steroids for recurrent uveitis postoperatively on three occasions in the same eye. B-scan ultrasonography showed multiple clumplike echoes suggestive of vitreous inflammation. Aqueous tap revealed Pseudomonas aeruginosa sensitive to ciprofloxacin. The patient was treated with intravitreal ciprofloxacin and vancomycin along with systemic ciprofloxacin with good clinical response. Even a virulent organism such as P.aeruginosa can present as a chronic uveitis, which, if missed, can lead to a delay in accurate diagnosis and appropriate management. |
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LETTERS TO THE EDITOR |
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Virtues of polymerase chain reaction in ophthalmology |
p. 311 |
Pulkit Gupta, BS Mahesh, HL Gupta DOI:10.4103/0301-4738.111190 PMID:23619492 |
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Our experience of fibrin sealant-assisted implantation of Ahmed glaucoma valve |
p. 311 |
Subashini Kaliaperumal DOI:10.4103/0301-4738.114126 PMID:23803485 |
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Authors' reply |
p. 312 |
Nikhil S Choudhari, Aditya Neog, Anuj Sharma, Geetha K Iyer, Bhaskar Srinivasan |
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