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  Indian J Med Microbiol
 

Figure 2: (a) Punch biopsy of upper eyelid lesion showed epidermal ulceration, with underlying pandermal and epidermotropic lymphocytic infiltrate, composed nearly entirely of large atypical lymphocytes, extending to and involving subcutis (H&E, ×40). (b) Composed predominantly of a diffuse monotonous population of large, cytologically atypical mononuclear cells, exhibiting nuclear pleomorphism, with hyperchromatic to vesicular convoluted nuclei, some with prominent nucleoli, and moderate amount of cytoplasm, comprising approximately 80% of total cellularity (H&E, ×100). (c) Immunohistochemically, large neoplastic lymphocytes showed predominantly cytotoxic phenotype with diffuse positivity for CD8, and essential negativity for CD4 (not shown)

Figure 2: (a) Punch biopsy of upper eyelid lesion showed epidermal ulceration, with underlying pandermal and epidermotropic lymphocytic infiltrate, composed nearly entirely of large atypical lymphocytes, extending to and involving subcutis (H&E, ×40). (b) Composed predominantly of a diffuse monotonous population of large, cytologically atypical mononuclear cells, exhibiting nuclear pleomorphism, with hyperchromatic to vesicular convoluted nuclei, some with prominent nucleoli, and moderate amount of cytoplasm, comprising approximately 80% of total cellularity (H&E, ×100). (c) Immunohistochemically, large neoplastic lymphocytes showed predominantly cytotoxic phenotype with diffuse positivity for CD8, and essential negativity for CD4 (not shown)