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Figure 2: Release kinetics of cefazolin from drug-laden HAM. The amount of cefazolin released from HAM buttons of different incubation periods (Group IA: Soaking duration 3 h at 4°C; Group IB: Soaking duration 3 h at RT; Group IIA: Soaking duration 24 h at 4°C; and Group IIB: Soaking duration 24 h at RT) is shown. Drug soaking at 4°C caused higher drug entrapment compared to RT at each time points studied; however, the release kinetics was not significantly different between the soaking temperatures used. *Comparison between Group IA and IIA; *P < 0.05; **P < 0.01; Mann–Whitney U-test. #Comparison between Group IA and IIA; #P < 0.05; ##P < 0.01; Mann–Whitney U-test |
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